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KMID : 0356419930110020063
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Journal of Korean Andrology
1993 Volume.11 No. 2 p.63 ~ p.68
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Relaxation of Internal Pudendal Artery by Acetylcholine is Involved in Penile Erection
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서무영
서준규/신현철/김영수/박동춘/변우목/조길호
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Abstract
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Recent in vitro studies have demonstrated that acetylcholine(ACh) relaxes cavernosal smooth muscle by causing the release of endothelium-derived relaxing factor(EDRF). However, it is not clear how the penile arterial system is involved in
erection
or
how autonomic nervous control affects the relaxation or contraction of that arterial system. The present study was designed to investigate the in vivo pharmacologic response of the internal pudendal artery(IPA) to intraarterial injection
injection
of
Can. Pudendal angiography was performed in 14 patients with venogenic impotence before and after injection of ACh(50㎍ or 100㎍)through the hypogastric artery. The ACh was found to increase the luminal diameter of the IPA in a dose-dependent
manner. The
dilating effect was more prominent in the distal portion(23.5;8.6%) than the proximal potion(15.1;6.0%) of the artery. These results, together with the previous in vitro data, indicate that ACh-induced relaxation of the IPA-penile arterial system
is
mediated by EDRF and the more distal branch of this arterial system may be actively involved in penile erection.
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KEYWORD
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